Discover how to get to Panamá on a Direct Flight from North America

Panamá offers 465 weekly direct flights to 26 cities in North America, making your trip easy without the need for connections or inconveniences. Start planning your adventure.

Below, you will find a guide with information about the nearest airport to your destination in Panamá, flight frequencies from your country of origin, and the airlines that operate these routes.

Direct flights from:

Canada, United States, Mexico

United States

The Statue of Liberty, a colossal copper statue of a woman holding a torch and a book, stands on Liberty Island in New York City. The statue is surrounded by water and skyscrapers in the background.

331 weekly flights to Panama City, Tocumen International Airport (PTY)

From Atlanta: Hartsfield-Jackson Atlanta International Airport (ATL)
From Austin: Austin–Bergstrom International Airport (AUS)
From Boston: Boston Logan International Airport (BOS)
From Chicago: Chicago O'Hare International Airport (ORD)
From Denver: Denver International Airport (DEN)
From Ft Lauderdale: Fort Lauderdale–Hollywood International Airport (FLL)
From Houston: George Bush Intercontinental Airport (IAH)
From Las Vegas: Harry Reid International Airport (LAS)
From Los Angeles: Los Angeles International Airport (LAX)
From Miami: Miami International Airport (MIA)
From New York City: John F. Kennedy International Airport (JFK), Newark Liberty International Airport (EWR)
From Orlando: Orlando International Airport (MCO)
From Raleigh Durham: Raleigh–Durham International Airport (RDU)
From San Diego: San Diego International Airport (SAN)
From San Francisco: San Francisco International Airport (SFO)
From Tampa: Tampa International Airport (TPA)
From Washington: Dulles International Airport (IAD), Baltimore/Washington International Thurgood Marshall Airport (BWI)

Airlines: Copa Airlines, American Airlines, United Airlines, Delta Airlines

Mexico

The iconic Temple of Kukulkan, at Chichen Itza in Mexico. The pyramid is bathed in golden light against a dramatic sunset sky.

108 weekly flights to Panama City, Tocumen International Airport (PTY)

From Cancún: Cancún International Airport (CUN)
From Guadalajara: Miguel Hidalgo y Costilla International Airport (GDL)
From Mexico City: Aeropuerto Internacional Benito Juárez (MEX) International Airport, Felipe Ángeles International Airport (NLU)
From Monterrey: General Mariano Escobedo International Airport (MTY)

New Direct Flight from Los Cabos to Panamá

3 weekly flights to Panama City, Tocumen International Airport (PTY)

From Los Cabos: Los Cabos International Airport (SJD)

Bookings Start: December 4, 2025

Airlines: Copa Airlines, Aeromexico

Canada

The CN Tower, a tall, iconic red and white tower, dominates the Toronto skyline. The tower stands tall above the city's skyscrapers, with Lake Ontario in the foreground and a dramatic sunset sky in the background.

17 weekly flights to Panama City, Tocumen International Airport (PTY)

From Montréal: Montréal-Pierre Elliott Trudeau International Airport (YUL)
From Toronto: Toronto Pearson International Airport (YYZ)

9 weekly flight to Rio Hato Scarlett Martinez International Airport (RIH)

From Montréal: Montréal-Pierre Elliott Trudeau International Airport (YUL)

New Direct Flight from Quebec to Panamá with WestJet

1 weekly flight to Panama City, Rio Hato Scarlett Martinez International Airport (RIH)

From Quebec: Québec City Jean Lesage International Airport (YQB)

Bookings Start: December 12, 2025

Airlines: Copa Airlines, Air Transat, WestJet