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Discover how to get to Panamá on a direct flight from Central America and the Caribbean

Panamá offers 406 weekly direct flights to 23 cities in Central America and the Caribbean, making your trip easy without the need for connections or inconveniences. Start planning your adventure.

Below, you will find a guide with information about the nearest airport to your destination in Panamá, flight frequencies from your country of origin, and the airlines that operate these routes.

Direct flights from:

Aruba, The Bahamas, Barbados, Belize, Costa Rica, Cuba, Curacao, El Salvador, Guatemala, Haiti, Honduras, Cayman Islands, Jamaica, Nicaragua, Puerto Rico, Dominican Republic, St. Martin, Trinidad and Tobago.

Dominican Republic

Aerial view of a tropical beach with white sand, palm trees, and a small lighthouse on a rocky outcropping. The water is turquoise and clear, with people swimming and sunbathing.

91 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Punta Cana: Punta Cana International Airport (PUJ)
  • From Santo Domingo: Las Américas International Airport (SDQ)

New Direct Flight from Santiago de los Caballeros to Panamá

3 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Santiago de los Caballeros: Cibao International Airport (STI)
  • Bookings Start: January 8, 2026

New Direct Flight from Puerto Plata to Panamá

2 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Puerto Plata: Gregorio Luperón International Airport (POP)

Airlines: Copa Airlines

Costa Rica

An aerial view of Lake Arenal, Costa Rica, with the Arenal Volcano in the background. The volcano is a cone-shaped peak with clouds around its summit. The lake is surrounded by lush green rainforest and a dam is visible on the left side of the image.

70 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From San José: Juan Santamaria International Airport (SJO)

10 weekly flights to Bocas del Toro Isla Colon Jose E. Hall International Airport (BOC)

  • From San José: Juan Santamaría International Airport (SJO)
  • From Puerto Limón: Limón International Airport (LIO)

Airlines: Copa Airlines, Avianca, Sansa Airlines, WDL Aviation

Guatemala

A colorful street in Antigua, Guatemala, with a yellow archway and a clock tower. The street is lined with brightly colored buildings, and a volcano with a cloud-covered peak rises in the background.

38 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Guatemala City: La Aurora International Airport (GUA)

Airlines: Copa Airlines

 

El Salvador

A scenic view of a volcanic landscape. A large, cone-shaped volcano dominates the center of the image,surrounded by lush green vegetation and colorful flowers.

32 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From San Salvador: El Salvador International Airport Saint Óscar Arnulfo Romero y Galdámez (SAL)

Airlines: Copa Airlines, Avianca

Cuba

A bustling street in Havana, Cuba, filled with colorful vintage cars. The iconic Capitol building with its dome is visible in the background, and palm trees line the street.

30 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Havana: José Martí international Airport (HAV)
  • From Santa Clara: Abel Santamaría International Airport (SNU)

4 weekly flights to Panama Pacific International Airport (BLB)

  • From Havana: José Martí international Airport (HAV)

Airlines: Copa Airlines, Wingo.

Honduras

An aerial view of a circular monument with a flagpole at its center. The monument is surrounded by trees and overlooks a city at sunset. The sky is filled with colorful clouds

26 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Comayagua: Comayagua International Airport (XPL)
  • From San Pedro Sula: Ramón Villeda Morales International Airport (SAP)

Airlines: Copa Airlines

Aruba

A lone Divi Divi tree with twisted branches leans towards the ocean on a sandy beach. A sailboat is visible in the distance.

16 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Aruba: Queen Beatrix International Airport (AUA)

Airlines: Copa Airlines

Puerto Rico

Ciudad del Viejo San Juan con casas coloridas y calle empedrada, Puerto Rico

14 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From San Juan: Luis Munoz Marin International Airport (SJU)

Airlines: Copa Airlines

Nicaragua

Aerial view of San Juan del Sur, Nicaragua. A crescent-shaped beach with white sand and turquoise water is surrounded by lush green hills. Boats are anchored in the bay, and colorful houses dot the landscape.

14 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Managua: Augusto Cesar Sandino International Airport (MGA)

Airlines: Copa Airlines

Curacao

Waterfront buildings with outdoor cafes, heart shape Love locks in Curacao

13 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Curaçao: Curaçao International Airport (CUR)

Airlines: Copa Airlines

Jamaica

A wooden signpost with a colorful oval sign reading "Caribbean Paradise Jamaica" and arrows pointing to different destinations in Jamaica: Kingston, Buff Bay, Montego Bay, Ocho Rios, Falmouth, and Negril.

13 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Kingston: Norman Manley International Airport (KIN)
  • From Montego Bay: Sangster International Airport (MBJ)

Airlines: Copa Airlines

Trinidad and Tobago

A historic brick building with a clock tower and intricate architectural details. The building is painted in shades of red and gray and is surrounded by palm trees.

10 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Port of Spain: Piarco International Airport (POS)

Airlines: Copa Airlines

The Bahamas

An aerial view of the iconic red and white striped lighthouse on Hog Island in the Bahamas. The lighthouse stands tall against a backdrop of turquoise water and lush greenery. Boats are docked nearby, and a small village is visible in the distance.

7 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Nassau: Lynden Pindling International Airport (NAS)

Airlines: Copa Airlines

Barbados

A row of brightly colored buildings with blue roofs and white picket fences line a sandy street. Tall palm trees sway in the breeze.

5 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Bridgetown: Grantley Adams International Airport (BGI)

Airlines: Copa Airlines

St. Martin

A scenic aerial view of Marigot, Saint Martin, at sunset. The town is nestled between hills, with colorful buildings and a vibrant waterfront. Boats are anchored in the harbor, and dramatic clouds fill the sky.

4 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From St Maarten: Princess Juliana International Airport (SXM)

Airlines: Copa Airlines

Belize

Aerial view of the Great Blue Hole, a massive circular underwater sinkhole surrounded by vibrant coral reefs in the Belize Barrier Reef.

2 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Belize: Philip Goldson International Airport (BZE)

Airlines: Copa Airlines

Cayman Islands

Stingray City in the Cayman Islands, destination known for its shallow blue waters and friendly stingrays

2 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Grand Cayman Is: Owen Roberts International Airport (GCM)

Airlines: Cayman Airways

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