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Discover how to get to Panamá on a direct flight from South America

Panamá offers 630 weekly direct flights to 32 cities in South America, making your trip easy without the need for connections or inconveniences. Start planning your adventure.

Below, you will find a guide with information about the nearest airport to your destination in Panamá, flight frequencies from your country of origin, and the airlines that operate these routes.

Direct flights from:

Colombia, Argentina, Bolivia, Brazil, Chile, Ecuador, Guyana, Paraguay, Peru, Suriname, Uruguay

Colombia

Colorful Guatape town colonial style architecture due to its tiles on its facades

253 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Barranquilla: Ernesto Cortissoz Barranquilla International Airport (BAQ)
  • To Bogotá: El Dorado International Airport (BOG)
  • To Bucaramanga: Palonegro International Airport (BGA)
  • To Cali: Alfonso Bonilla Aragón International Airport (CLO) 
  • To Cartagena: Rafael Núñez International Airport (CTG)
  • To Cúcuta: Camilo Daza International Airport (CUC)
  • To Medellín: Jose Maria Cordova International Airport (MDE)
  • To Pereira: Matecaña International Airport (PEI)
  • To San Andrés Island: Gustavo Rojas Pinilla International Airport (ADZ)
  • To Santa Marta: Simón Bolívar International Airpor (SMR)

21 weekly flights from Panama Pacific International Airport (BLB)

  • To Barranquilla: Ernesto Cortissoz Barranquilla International Airport (BAQ)
  • To Bogotá: El Dorado International Airport (BOG)
  • To Cali: Alfonso Bonilla Aragón International Airport (CLO) 
  • To Cartagena: Rafael Núñez International Airport (CTG)
  • To Medellín: Jose Maria Cordova International Airport (MDE)

Airlines: Copa Airlines, Wingo, Avianca

Argentina

The Obelisk of Buenos Aires, a tall white monument, stands tall in the center of a busy city street. Buildings line the sides of the street, and an Argentine flag is visible flying from one of them.

61 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Buenos Aires: Ezeiza International Airport (EZE)
  • To Córdoba: Ingeniero Aeronáutico Ambrosio L.V. Taravella International Airport (COR)
  • To Rosario: Rosario – Islas Malvinas International Airport (ROS)
  • To Mendoza: El Plumerillo International Airport (MDZ) 

Airlines: Copa Airlines

Bolivia

A vast, flat salt pan with hexagonal patterns formed by salt crystals. The sky is a vibrant orange and pink at sunset, and mountains can be seen in the distance.

7 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Santa Cruz: Viru Viru International Airport (VVI)

Airlines: Copa Airlines

Brazil

An aerial view of Rio de Janeiro, Brazil, featuring the iconic Christ the Redeemer statue atop Corcovado Mountain. The city is spread out below, with Guanabara Bay and Sugarloaf Mountain visible in the distance.

83 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To São Paulo: São Paulo-Guarulhos International Airport (GRU)
  • To Rio de Janeiro: Galeão International Airport (GIG)
  • To Belo Horizonte: Aeropuerto Internacional Tancredo Neves (CNF)
  • To Brasilia: Brasilia International Airport (BSB)
  • To Manaus: Eduardo Gomes International Airport (MAO)
  • To Florianopolis: Florianópolis–Hercílio Luz International Airport(FLN)
  • To Porto Alegre:  Salgado Filho International Airport (POA)

Airlines: Copa Airlines

Chile

Several large, stone Moai statues standing in a field on Easter Island. The statues have elongated ears and stoic expressions, with a backdrop of rolling hills and a blue sky.

35 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Santiago: Arturo Merino Benitez International Airport (SCL)

Airlines: Copa Airlines

Ecuador

Two sea lions lounging on a sandy beach, with a clear blue sky and turquoise water in the background. A boat is anchored offshore, and rocky islands are visible in the distance

75 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Guayaquil: José Joaquín de Olmedo International Airport (GYE)
  • To Manta: Eloy Alfaro International Airport (MEC)
  • To Quito: Mariscal Sucre Quito International Airport (UIO)

6 weekly flights from Panama Pacific International Airport (BLB)

  • To Quito: Mariscal Sucre Quito International Airport (UIO)

Airlines: Copa Airlines, Euroairlines, Go2Sky

Guyana

A historical building with a tall, Gothic-style tower and a statue of Queen Victoria in front of it. The building has a blue and white facade and a sloped roof. A flag of Guyana is flying at the top of the tower.

7 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Georgetown: Cheddi Jagan International Airport (GEO)

Airlines: Copa Airlines

Paraguay

A large, ornate building with a central tower and a Paraguayan flag flying from its top. The building is surrounded by palm trees and a manicured lawn.

14 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Asunción: Silvio Pettirossi International Airport (ASU)

Airlines: Copa Airlines

Peru

A panoramic view of Machu Picchu, a UNESCO World Heritage Site in Peru. The ancient Incan citadel is perched high in the Andes Mountains, surrounded by lush green terraces and dramatic mountain peaks.

44 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Lima: Jorge Chavez International Airport (LIM)
  • To Chiclayo: Chiclayo's Capitan Jose A. Quiñones Gonzalez International Airport (CIX)

Airlines: Copa Airlines

Suriname

A row of historic buildings with red brick facades and white trim line a street. Palm trees sway in the breeze, and a clear blue sky is visible above.

3 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Paramaribo: Johan Adolf Pengel International Airport (PBM)

Airlines: Copa Airlines

Uruguay

Alt Text: A grand, ornate building with a dome and a tower stands tall in a city square. Palm trees line the sides of the square, and a statue of a man on horseback is visible in the foreground.

21 weekly flights from Panama City, Tocumen International Airport (PTY)

  • To Montevideo: Carrasco International Airport (MVD)

Airlines: Copa Airlines

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