Discover how to get to Panamá on a direct flight from Central America and the Caribbean

Panamá offers 384 weekly direct flights to 18 cities in Central America and the Caribbean, making your trip easy without the need for connections or inconveniences. Start planning your adventure.

Below, you will find a guide with information about the nearest airport to your destination in Panamá, flight frequencies from your country of origin, and the airlines that operate these routes.

Direct flights from:

Aruba, The Bahamas, Barbados, Belize, Costa Rica, Cuba, Curacao, El Salvador, Guatemala, Haiti, Honduras, Cayman Islands, Jamaica, Nicaragua, Puerto Rico, Dominican Republic, St. Martin, Trinidad and Tobago.

Dominican Republic

Aerial view of a tropical beach with white sand, palm trees, and a small lighthouse on a rocky outcropping. The water is turquoise and clear, with people swimming and sunbathing.

84 weekly flights to Panama City, Tocumen International Airport (PTY)

From Punta Cana: Punta Cana International Airport (PUJ)
From Santo Domingo: Las Américas International Airport (SDQ)

New Direct Flight from Santiago de los Caballeros to Panamá

3 weekly flights to Panama City, Tocumen International Airport (PTY)

From Santiago de los Caballeros: Cibao International Airport (STI)

Bookings Start: January 8, 2026

Airlines: Copa Airlines

Costa Rica

An aerial view of Lake Arenal, Costa Rica, with the Arenal Volcano in the background. The volcano is a cone-shaped peak with clouds around its summit. The lake is surrounded by lush green rainforest and a dam is visible on the left side of the image.