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Discover how to get to Panamá on a direct flight from South America

Panamá connects 668 weekly direct flights to 34 cities in South America, making your trip easy without the need for connections or inconveniences. Start planning your adventure.

Below, you will find a guide with information about the nearest airport to your destination in Panamá, flight frequencies from your country of origin, and the airlines that operate these routes.

Direct flights from:

Colombia, Argentina, Bolivia, Brazil, Chile, Ecuador, Guyana, Paraguay, Peru, Suriname, Uruguay, Venezuela

Colombia

Colorful Guatape town colonial style architecture due to its tiles on its facades

246 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Barranquilla: Ernesto Cortissoz Barranquilla International Airport (BAQ)
  • From Bogotá: El Dorado International Airport (BOG)
  • From Bucaramanga: Palonegro International Airport (BGA)
  • From Cali: Alfonso Bonilla Aragón International Airport (CLO) 
  • From Cartagena: Rafael Núñez International Airport (CTG)
  • From Cúcuta: Camilo Daza International Airport (CUC)
  • From Medellín: Jose Maria Cordova International Airport (MDE)
  • From Pereira: Matecaña International Airport (PEI)
  • From San Andrés Island: Gustavo Rojas Pinilla International Airport (ADZ)
  • From Santa Marta: Simón Bolívar International Airpor (SMR)

23 weekly flights to Panama Pacific International Airport (BLB)

  • From Barranquilla: Ernesto Cortissoz Barranquilla International Airport (BAQ)
  • From Bogotá: El Dorado International Airport (BOG)
  • From Cali: Alfonso Bonilla Aragón International Airport (CLO) 
  • From Cartagena: Rafael Núñez International Airport (CTG)
  • From Medellín: Jose Maria Cordova International Airport (MDE)

Airlines: Copa Airlines, Wingo, Avianca

Brazil

An aerial view of Rio de Janeiro, Brazil, featuring the iconic Christ the Redeemer statue atop Corcovado Mountain. The city is spread out below, with Guanabara Bay and Sugarloaf Mountain visible in the distance.

83 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From São Paulo: São Paulo-Guarulhos International Airport (GRU)
  • From Rio de Janeiro: Galeão International Airport (GIG)
  • From Belo Horizonte: Aeropuerto Internacional Tancredo Neves (CNF)
  • From Brasilia: Brasilia International Airport (BSB)
  • From Manaus: Eduardo Gomes International Airport (MAO)
  • From Florianopolis: Florianópolis–Hercílio Luz International Airport(FLN)
  • From Porto Alegre:  Salgado Filho International Airport (POA)

New Direct Flight from Salvador de Bahía to Panamá

4 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Salvador de Bahía: Salvador Deputy Luís Eduardo Magalhães International Airport (SSA)

  • Bookings open: January 8, 2026
     

Airlines: Copa Airlines

Ecuador

Two sea lions lounging on a sandy beach, with a clear blue sky and turquoise water in the background. A boat is anchored offshore, and rocky islands are visible in the distance

77 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Guayaquil: José Joaquín de Olmedo International Airport (GYE)
  • From Manta: Eloy Alfaro International Airport (MEC)
  • From Quito: Mariscal Sucre Quito International Airport (UIO)

6 weekly flights to Panama Pacific International Airport (BLB)

  • From Quito: Mariscal Sucre Quito International Airport (UIO)

Airlines: Copa Airlines, Euroairlines, Go2Sky

Argentina

The Obelisk of Buenos Aires, a tall white monument, stands tall in the center of a busy city street. Buildings line the sides of the street, and an Argentine flag is visible flying from one of them.

75 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Buenos Aires: Ezeiza International Airport (EZE)
  • From Córdoba: Ingeniero Aeronáutico Ambrosio L.V. Taravella International Airport (COR)
  • From Rosario: Rosario – Islas Malvinas International Airport (ROS)
  • From Mendoza: El Plumerillo International Airport (MDZ) 

Airlines: Copa Airlines

Peru

A panoramic view of Machu Picchu, a UNESCO World Heritage Site in Peru. The ancient Incan citadel is perched high in the Andes Mountains, surrounded by lush green terraces and dramatic mountain peaks.

44 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Lima: Jorge Chavez International Airport (LIM)
  • From Chiclayo: Chiclayo's Capitan Jose A. Quiñones Gonzalez International Airport (CIX)

Airlines: Copa Airlines

Chile

Several large, stone Moai statues standing in a field on Easter Island. The statues have elongated ears and stoic expressions, with a backdrop of rolling hills and a blue sky.

36 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Santiago: Arturo Merino Benitez International Airport (SCL)

Airlines: Copa Airlines

Uruguay

Alt Text: A grand, ornate building with a dome and a tower stands tall in a city square. Palm trees line the sides of the square, and a statue of a man on horseback is visible in the foreground.

20 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Montevideo: Carrasco International Airport (MVD)

Airlines: Copa Airlines

Venezuela

A towering waterfall, known as Angel Falls in Venezuela, plummets from a flat-topped mountain, surrounded by lush, green jungle.

 

19 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Caracas: Simón Bolívar International Airport (CCS)

Airlines: Copa Airlines, Estelar

Paraguay

A large, ornate building with a central tower and a Paraguayan flag flying from its top. The building is surrounded by palm trees and a manicured lawn.

14 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Asunción: Silvio Pettirossi International Airport (ASU)

Airlines: Copa Airlines

Bolivia

A vast, flat salt pan with hexagonal patterns formed by salt crystals. The sky is a vibrant orange and pink at sunset, and mountains can be seen in the distance.

10 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Santa Cruz: Viru Viru International Airport (VVI)

Airlines: Copa Airlines

Guyana

A historical building with a tall, Gothic-style tower and a statue of Queen Victoria in front of it. The building has a blue and white facade and a sloped roof. A flag of Guyana is flying at the top of the tower.

7 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Georgetown: Cheddi Jagan International Airport (GEO)

Airlines: Copa Airlines

Suriname

A row of historic buildings with red brick facades and white trim line a street. Palm trees sway in the breeze, and a clear blue sky is visible above.

4 weekly flights to Panama City, Tocumen International Airport (PTY)

  • From Paramaribo: Johan Adolf Pengel International Airport (PBM)

Airlines: Copa Airlines

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